How Augmented Ai can predict complications of Diabetes using Genomics and Precision Pharmacotherapy
Authors: Kirtana Roopan, Ezekiel Mendoza, BS, Zain Khalpey, MD, PhD, FACS
Augmented AI: A powerful potential tool for predicting complications of Diabetes using Genomics and Precision Pharmacotherapy
Introduction
In recent years, the use of augmented artificial intelligence (AAI) has shown great potential in predicting and preventing complications of diabetes. Genomics and precision pharmacotherapy are two areas where AAI can be particularly effective in identifying patients who are at high risk of developing complications and providing personalized treatment options. By analyzing large amounts of genomic and pharmacological data, AAI can provide insights that can help healthcare providers develop targeted treatments for patients with diabetes.
Genomics and Diabetes
Genomics is the study of an individual’s genetic makeup, including DNA and RNA sequencing. It can provide valuable information on an individual’s predisposition to certain diseases and identify factors that contribute to the onset, severity and complications. Additionally, it is ensured in genomics that the genetic component is not affected by the disease or its treatment. Genomics focuses on the contribution of these genetic components to the phenotype, i.e. the diabetes and its complications. The precise sequences and mutations that contribute to a patient’s diabetes can be identified and a specific treatment can be tailored accordingly. This is the idea of precision medicine, and it has great prospects, especially for multifactorial diseases like diabetes that have major genetic contributors.
In addition, AAI can analyze gene mutations that affect insulin secretion or sensitivity, as well as genes that affect the metabolism of glucose and lipids. AAI can provide personalized recommendations for lifestyle modifications, medication use, and other interventions that can help reduce the risk of complications.
Applications of AAI
Precision pharmacotherapy is another area where AAI can be particularly effective. This approach involves tailoring drug treatments to an individual’s specific genetic and physiological characteristics. By analyzing a patient’s genomic data and other physiological data, AAI can predict how a patient is likely to respond to different medications. This can help healthcare providers develop personalized and optimal treatment plans. For example, AAI can predict which patients are at high risk of developing complications from certain diabetes medications, and recommend alternative medications that are less likely to cause unwanted side effects.
Another way that AAI can help in predicting complications of diabetes is by integrating data from various sources. By analyzing data from electronic health records (EHR), genomics, and precision pharmacotherapy, AAI can develop a more comprehensive understanding of a patient’s health status so it can integrate with their current medication use and lifestyle factors.
Conclusion
In conclusion, AAI has shown great potential in predicting complications of diabetes by analyzing genomics and precision pharmacotherapy. By analyzing large amounts of data from various sources, AAI can provide personalized recommendations that can help reduce the risk of complications and improve patient outcomes. As this technology continues to evolve, it is likely to become an invaluable tool in the fight against diabetes and other chronic diseases.
References
1. Florez JC. Precision Medicine in Diabetes: Is It Time? Diabetes Care. 2016 Jul;39(7):1085-8.
2. Xie F, Chan JC, Ma RC. Precision medicine in diabetes prevention, classification and management. J Diabetes Investig. 2018 Sep;9(5):998-1015.
3. Rashid J, Batool S, Kim J, Wasif Nisar M, Hussain A, Juneja S, Kushwaha R. An Augmented Artificial Intelligence Approach for Chronic Diseases Prediction. Front Public Health. 2022 Mar 31;10:860396. doi: 10.3389/fpubh.2022.860396. PMID: 35433587; PMCID: PMC9008324.
